HOME Research Heterodimeric Fc-based bispecific antibody
Heterodimeric Fc technology for bispecific antibody
Bispecific antibodies which are able to bind simultaneously with two different targets have various advantages such as overcoming resistance of single drug, increasing efficacy and reducing production expense. Therefore, many multinational biotech firm/pharmaceuticals have been trying to develop various formats for generation of bi/multi-specific antibodies. Heterodimeric Fc is one of the attractive platform technology that facilitate construction of bispecific antibodies with IgG-like format as well as Fc-fusion proteins.
We have developed high yield heterodimeric Fc technology by engineering CH3 interface of IgG. Heterodimeric Fc not only retain natural Fc properties, including physicochemical stability, long serum half-life, and immune system recruiting ability but also minimize potential immunogenicity caused by artificial mutation. Heterodimer Fc technology can be applied for generation of potent therapeutic antibodies and proteins.