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  • 작성일 2017-08-04 09:42:33
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2017. 06. 29.


  Nature Communications 에 기재된 'Antibody targeting intracellular oncogenic Ras mutants exerts
 anti-tumor effects systemic administration.' 논문이 F1000Prime 에 Article Recommendations 로
 highlight 되었습니다.

 While antibody administration has become entrenched as a viable therapeutic option, 
 especially for oncologic applications, targets have been limited to extracellular components due to 
 inability to traverse the plasma membrane. Shin et al. describe a novel methodology that targets 
 monoclonal antibodies to a cytoplasmic compartment by the addition of a "homing peptide" that 
 binds to a tumor-associated integrin allowing for internalization with eventual endosomal escape 
 into the cytoplasm demonstrating activity against a Ras mutant, providing proof of principle for this 
 concept. While these "internalizing" MAbs (iMAbs) currently suffer from poor endosomal escape 
 and a short half-life in circulation, these deficiencies appear more as technical concerns, 
 rather than fundamental impediments. The ability to selectively direct MAbs to cytoplasmic targets 
 could herald a new technical approach to address a wide range of medical conditions.

 Recommended by Michael Kurilla and Randall Kincaid.


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